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Sperm-derived circRNA-1572 regulates embryogenesis and zygotic genome activation by targeting CCNB2 via bta-miR-2478-L-2 [miRNA-seq]

ABSTRACT: This study identified circRNA-1572, which is delivered by sperm into the oocyte during fertilization, whose downregulation resulted in developmental arrest and inhibition of ZGA during porcine embryogenesis. Moreover, we elucidated that sperm-derived circRNA-1572 competitively binds to bta-miR-2478-L-2 through a “sponge” mechanism to target and regulate cyclin B2 expression, thereby modulating the distribution of F-actin in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage, maternal RNA degradation (MRD), and ZGA.

ORGANISM(S): Sus scrofa

PROVIDER: GSE288538 | GEO | 2025/05/29

REPOSITORIES: GEO

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