Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28876 | GEO | 2012/09/13

SECONDARY ACCESSION(S): PRJNA140597

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest

Project description:This SuperSeries is composed of the following subset Series: GSE28874: Genome-wide analysis of p300, H3K4me3, H3K4me1, H3K27me3 and H3K27ac in in vitro differentiated human neural crest cells (hNCC) GSE28875: RNA-seq experiments in human neural crest cells (hNCC) Refer to individual Series

2012-09-13 | E-GEOD-28876 | biostudies-arrayexpress

Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest.

Project description:Combining an in vitro hNCC differentiation protocol with epigenomic profiling, we provide the first whole-genome characterization of cis-regulatory elements in this highly relevant cell type. With this data at hand, we have characterized the chromatin state and dynamics of all human gene promoters during the course of NCC in vitro differentiation. Most importantly, we have identified a large cohort of active and NCC-specific enhancers, which we showed to be functionally relevant in vivo, in the context of embryonic development. Finally, through sequence analysis of the identified NCC enhancers, we uncovered the orphan nuclear receptors NR2F1 and NR2F2 as novel hNCC transcriptional regulators both in vitro and in vivo. Genome-wide analysis of H3K27ac in chicken neural crest cells (NCC) obtained from stage 11-14 or stage 20 embryos

2012-09-13 | E-GEOD-38066 | biostudies-arrayexpress

Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest.

2012-09-13 | GSE38066 | GEO

Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest

Project description:Epigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest

| PRJNA140597 | ENA

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.

Project description: Not available

| S-EPMC3751405 | biostudies-literature

Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.

Project description: Not available

| S-EPMC4221282 | biostudies-literature

Study of Genetic Polymorphisms of Drug Transporters and Orphan Nuclear Receptors on Treatment Effects of Irinotecan

Project description:From 100 colorectal cancer patients being treated with FOLFIRI regimen or any kind of irinotecan containing regimen, blood samples for irinotecan and its metabolites levels and genotypes related with its metabolism will be collected. The association of their levels and genotypes and treatment effects will be evaluated.

| 2042525 | ecrin-mdr-crc

Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.

Project description: Not available

| S-EPMC6961570 | biostudies-literature

Human genetic variation within neural crest enhancers: molecular and phenotypic implications.

Project description: Not available

| S-EPMC3682725 | biostudies-literature

Orphan nuclear receptors as targets for drug development.

Project description: Not available

| S-EPMC3518931 | biostudies-literature