Genomics

Dataset Information

0

RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling


ABSTRACT: Ligand activation of nuclear receptor has been linked with therapeutic implications in Alzheimer's Disease. In this study, we used AD mouse model treated with Bexarotene, an RXR agonist and performed scRNA-seq and snATAC-seq using the brain tissue. We reavealed changes in chromatin architure in brain of AD-lie mouse model in response to RXR ligand and link those changes to the initiation of transcriptional programs at a single-cell resolution.

ORGANISM(S): Mus musculus

PROVIDER: GSE289039 | GEO | 2025/12/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
GSE289039_finalhits_clean.bed.gz Bed
Items per page:
1 - 2 of 2

Similar Datasets

2025-12-11 | GSE283906 | GEO
2012-01-31 | E-GEOD-35262 | biostudies-arrayexpress
2023-02-21 | GSE211290 | GEO
2012-01-31 | GSE35262 | GEO
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
2021-10-19 | GSE119824 | GEO
2024-11-09 | GSE280976 | GEO
2025-01-07 | GSE285893 | GEO
2025-02-24 | GSE290329 | GEO
2025-02-24 | GSE290328 | GEO