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ScRNA-sequencing of gastric tissues derived from three inflamed-type and three desert-type tumors

ABSTRACT: Transforming gastric tumors from immunosuppressive to immunostimulatory is a potential approach to enhance immune checkpoint blockade response. Here, we developed a chromosomal instability subtype gastric cancer mouse model with an immunoactive tumor microenvironment (TME) and a stem cell-originated mouse-derived allograft model with an immunosuppressed TME to investigate mechanisms regulating the tumor immunophenotype and uncover therapeutic strategies to remodel the TME.

ORGANISM(S): Mus musculus

PROVIDER: GSE289116 | GEO | 2025/02/18

REPOSITORIES: GEO

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