To analyze expression in the conjunctival epithelium of patients with severe dry eye disease

ABSTRACT: In 2005, we determined the glyco-gene expression profile of three normal subjects ( www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27593). This led to information on the biosynthesis of mucin O-glycans and glycoproteins that may be involved in the protection of the ocular surface. The interaction of the most highly expressed glycoprotein identified by the glyco-gene chip, galectin-3, with other ligands at the ocular surface (i.e., mucin O-glycans), is now under intense study in our laboratory, and has lead to a collaboration with another group in the glycobiology field.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28941 | GEO | 2011/04/29

SECONDARY ACCESSION(S): PRJNA139901

REPOSITORIES: GEO