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Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility [snRNA-seq]

ABSTRACT: The native microbiome influences a plethora of host processes, including neurological function. However, its impacts on diverse brain cell types remains poorly understood. Here, we performed single nucleus RNA sequencing on hippocampi from wildtype, germ-free mice and reveal the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways, underscoring the microbiome’s contributions to disease-relevant processes. In addition, mono-colonization with Escherichia coli was found to induce a distinct adaptive immune and neurogenerative disease-associated cell state, suggesting increased disease susceptibility.

ORGANISM(S): Mus musculus

PROVIDER: GSE289589 | GEO | 2026/02/03

REPOSITORIES: GEO

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