Transcriptomics

Dataset Information

0

FXR protects against neonatal sepsis via enhancing the immunosuppressive function of MDSCs


ABSTRACT: The presence of myeloid-derived suppressor cells (MDSCs) during the early postnatal period plays a protective role against neonatal inflammation. However, the mechanisms regulating neonatal MDSCs remain to be fully elucidated. In this study, we report that the bile acid receptor Farnesoid X receptor (FXR) acts as a pivotal positive regulator of neonatal MDSCs. Using FXR-deficient (FXR-/-) mice and FDA-approved FXR agonist obeticholic acid (OCA), we demonstrated that FXR deficiency impairs the immunosuppressive and antibacterial functions of neonatal MDSCs, thereby exacerbating the severity of neonatal sepsis. Adoptive transfer of MDSCs alleviates sepsis severity in FXR-/- neonatal pups. Mechanistic studies reveal that HIF1a, a well-established regulator of MDSCs, is a direct transcriptional target of FXR. Patients with neonatal sepsis displayed reduced MDSC frequencies and impaired expression of FXR and HIF-1α, which was negatively correlate with the clinical parameters. These observations highlight the important role of FXR in neonatal MDSCs and its therapeutic potential in neonatal sepsis.

ORGANISM(S): Mus musculus

PROVIDER: GSE289598 | GEO | 2025/05/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-01-27 | E-GEOD-73624 | biostudies-arrayexpress
2020-07-27 | GSE133659 | GEO
2016-01-27 | GSE73624 | GEO
2020-07-27 | GSE133734 | GEO
2020-07-27 | GSE133700 | GEO
2016-01-27 | GSE76162 | GEO
2016-01-27 | GSE76161 | GEO
2020-05-01 | GSE138810 | GEO
| PRJNA1223799 | ENA
2019-08-20 | GSE129389 | GEO