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Escape from X inactivation is directly modulated by Xist non-coding RNA [ESC]

ABSTRACT: X-chromosome inactivation silences one copy of the X-chromosome in female cells, but a number of genes escapes this inactivation. We asked whether increased levels of Xist RNA, the molecular actor driving X-inactivation, impacts expression levels of escapees. To this end, we performed transcriptomic profiling of X-linked gene expression in clonal neural progenitor cell lines with transgenes that allow for the overexpression of Xist on the inactive X chromosome. Here, we use the F1 hybrid mouse ESC line from which the NPCs were derived as a control to assess the silencing effect of Xist in ESCs.

ORGANISM(S): Mus

PROVIDER: GSE289901 | GEO | 2025/12/09

REPOSITORIES: GEO

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