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In vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes

ABSTRACT: We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE29009 | GEO | 2011/12/29

SECONDARY ACCESSION(S): PRJNA140461

REPOSITORIES: GEO

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In vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes

Project description:We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response. We first pretreated HeLa cells with control siRNA or LAMP3 siRNA overnight and then added 1 ng/ml of interferon alpha to the cultures for 3 and 4 days

2011-12-29 | E-GEOD-29009 | biostudies-arrayexpress

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