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Single-cell RNA sequencing of Porphyromonas gingivalis reveals heterogeneity and rare cellular states in laboratory medium.

ABSTRACT: Porphyromonas gingivalis is a Gram-negative anaerobic bacterium linked to chronic periodontitis and systemic diseases. Understanding its cellular heterogeneity is crucial for elucidating its adaptive mechanisms and virulence regulation. This study employs single-cell RNA sequencing using the split-pool barcoding method to capture transcriptomic variability within P. gingivalis populations. The results provide insights into gene expression diversity under laboratory growth conditions, revealing potential subpopulations that contribute to bacterial survival and pathogenicity.

ORGANISM(S): Porphyromonas gingivalis

PROVIDER: GSE290203 | GEO | 2025/08/05

REPOSITORIES: GEO

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