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Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy II

ABSTRACT: To confirm that both pro-inflammatory and immunosuppressive subsets arise from common monocyte precursors, we employed Ms4a3-Cre Rosa26-tdTomato fate-mapping mice. Flow cytometry of dissociated tumors showed that most F4/80+ macrophages were tdTomato+, with subpopulations differing in MHC class II expression. scRNA-seq of sorted CD45+tdTomato+ cells confirmed a bifurcated differentiation trajectory that yields pro-inflammatory, MHC II–high macrophages (Cxcl9+, H2-Eb1), as well as Spp1+ Arg1+ immunocompromised phenotypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE290326 | GEO | 2025/10/10

REPOSITORIES: GEO

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Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy

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Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy

Project description:Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy

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Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy II

Project description:Rebound Polarization of Monocyte-derived Tumor Macrophages Under Repeated Anti-CD40 Immunotherapy II

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An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment

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Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages

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2016-12-31 | GSE77208 | GEO

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