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Lysosomes Signal through Epigenome to Regulate Longevity across Generations [II]

ABSTRACT: Profiling of H3K79me2 occupancy in F3 wild-type progeny, designated as second transgenerational (T2) descendants, derived from N2, lipl-4 Tg, or dot-1.3 Tg parents.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE290404 | GEO | 2025/06/30

REPOSITORIES: GEO

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Lysosomes Signal through Epigenome to Regulate Longevity across Generations [I]

Project description:Profiling of H3K79me2/3 occupany between wild-type N2 worms and lipl-4 transgenic (lipl-4 Tg) worms.

2025-06-30 | GSE235724 | GEO

Lysosomes Signal through Epigenome to Regulate Longevity across Generations [III]

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Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep

Project description:Despite two extensive reprogramming events during early embryogenesis and game-togenesis, epigenetic information can be passed to the next generations, which consti-tutes transgenerational epigenetic inheritance of phenotypes. Considering its utmost importance, there have been few studies focused on the transgenerational effects of di-etary interventions, such as methionine supplementation, in livestock. Using whole-genome bisulfite sequencing, we implemented a single-base resolution differen-tial methylation analysis for the F3 and F4 descendants of control vs. methio-nine-supplemented F0 twin-pair rams. Based on the results of our previous study on F0, F1, and F2 generations, we compared current results of 2,981 and 1,726 differen-tially methylated cytosines (DMCs) as well as 798 and 553 unique differentially meth-ylated genes (DMGs) in F3 and F4, respectively. We identified 41 DMGs that exhibited transgenerational epigenetic inheritance (TEI-DMGs) across four generations and 11 TEI-DMGs across five generations. Finally, we estimated the effect size of F0 diet group on F3 and F4 growth and fertility-related phenotypes, providing evidence for transgenerational effects of diet group accompanying inherited differentially methyl-ated genes. Here, for the first time using gene-level and phenotypic data, we demon-strate that a moderate dietary intervention can exert long-lasting transgenerational effects on offspring phenotypes extending beyond the F2 generation in sheep.

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Lysosomes Signal through Epigenome to Regulate Longevity across Generations [III]

Project description:Lysosomes Signal through Epigenome to Regulate Longevity across Generations [III]

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Lysosomes Signal through Epigenome to Regulate Longevity across Generations [I]

Project description:Lysosomes Signal through Epigenome to Regulate Longevity across Generations [I]

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Lysosomes Signal through Epigenome to Regulate Longevity across Generations [II]

Project description:Lysosomes Signal through Epigenome to Regulate Longevity across Generations [II]

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Synthetic apomixis transfers stably over multiple generations in hybrid rice

Project description:we reproduced the clonal plants of Fix (Fixation of rice heterozygosity) to T4 generation with 1.9~3.2% clonal seeds rate of Fix-T01th, T12th, T23th and T34th. The descendant clonal plants Fix-T0, T1, T2, T3 and T4 exhibited no discernible differences on plant morphology, clonal seeds rate (3.7~4.3%), genome, methylome and transcriptome. Unexpectedly, few aneuploids were identified in each generation. The visible morphology changes of aneuploids might be caused by chromosome segments elimination. Together, the synthetic apomixis was heritable through multiple generations and few aneuploids were induced when using the synthetic apomixis system.

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Mercury-Induced Epigenetic Transgenerational Inheritance of Abnormal Neurobehavior is Correlated with Sperm Epimutations in Zebrafish

Project description:Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure and transgenerational effects of MeHg, at tissue doses similar to those detected in exposed human populations, on sperm epimutations (i.e., differential DNA methylation regions [DMRs]) and neurobehavior (i.e., visual startle and spontaneous locomotion) in zebrafish, an established human health model. F1 generation embryos were exposed to MeHg (0, 1, 3, 10, 30, and 100 nM) for 24 hours ex vivo. F1 generation control and MeHg-exposed lineages were reared to adults and bred to yield the F2 generation, which was subsequently bred to the F3 generation. Direct exposure (F1 generation) and transgenerational actions (F3 generation) were then evaluated. Hyperactivity and visual deficit were observed in the unexposed descendants (F3 generation) of the MeHg-exposed lineage compared to control. An increase in F3 generation sperm epimutations was observed relative to the F1 generation. Investigation of the DMRs in the F3 generation MeHg-exposed lineage sperm revealed associated genes in the neuroactive ligand-receptor interaction and actin-cytoskeleton pathways being effected, which correlate to the observed neurobehavioral phenotypes. Developmental MeHg-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in F3 generation adult zebrafish. Therefore, mercury has the ability to promote the epigenetic transgenerational inheritance of disease in zebrafish, which significantly impacts its environmental health considerations in all species including humans.

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Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines.

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| S-EPMC6901263 | biostudies-literature

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