Modeling NRF2-Driven Anti-inflammatory, Tumor-promoting Macrophages In Vitro
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ABSTRACT: To determine whether NRF2-mediated anti-inflammatory differentiation and its downstream consequences on tumor immunology are intrinsic macrophage processes, we conducted a series of in vitro studies. First, we performed scRNA-seq studies of WT, Keap1 KO, and Nrf2 KO BMDMs after short-term culture with GM-CSF for 5 days to capture a broad spectrum of differentiation and polarization states across the macrophage lineage trajectory.
ORGANISM(S): Mus musculus
PROVIDER: GSE290431 | GEO | 2025/10/10
REPOSITORIES: GEO
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