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Single cell transcriptomic analysis of nephron and UB lineages in recombinant hPSC-derived kidney organoids grown under various conditions.

ABSTRACT: To model tissue interactions in kidney development, a protocol was devised to combine human pluripotent stem cell (hPSC)-derived ureteric bud progenitors with nephrogenic mesenchyme to form kidney organoids. The resulting organoids had a complex composition including the nephron, ureteric, stromal, and endothelial lineages. scRNA-seq was performed to catalog and analyze the populations and developmental trajectories of the different lineages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE290442 | GEO | 2025/05/07

REPOSITORIES: GEO

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Single cell transcriptomic analysis of nephron and UB lineages in recombinant hPSC-derived kidney organoids grown under various conditions.

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