Enhancer-associated LncRNA-ITGA2 promotes vascular smooth muscle remodeling by mediating ITGA2 promoter-enhancer interactions [RNA-seq]

ABSTRACT: To characterize the effects of PDGF-BB on long non-coding RNA (lncRNA) expression in vascular smooth muscle cells (VSMCs). Primary human VSMCs were cultured and treated with PDGF (20 ng/mL) or vehicle control (Veh) for 24 hours. Then we conducted lncRNA-seq and observed an increased in LncRNA-ITGA2 transcript reads following PDGF-BB treatment. This result is consistent with our microarray findings.

ORGANISM(S): Homo sapiens

PROVIDER: GSE290463 | GEO | 2025/12/31

REPOSITORIES: GEO