Single-cell transcriptomic analysis of zebrafish fli1b mutants
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ABSTRACT: To characterize fli1b role in zebrafish hematopoietic development, we obtained samples from zebrafish fli1b mutant and control wild-type embryos at 23-24 hpf stage. Whole embryo single-cell RNA-seq demonstrated reduction in the expression of hematopoietic markers associated with erythroid and myeloid development. A subset of vascular endothelial markers was also reduced in fli1b mutants. These results demonstrate fli1b role in hematopoietic and vascular development.
ORGANISM(S): Danio rerio
PROVIDER: GSE290550 | GEO | 2025/03/26
REPOSITORIES: GEO
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