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Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer

ABSTRACT: The goal of this study was to employ a single cell RNA sequencing approach to determine cell population differences between wildtype and DPEP1 KO mice that were induced to form distal colonic tumors by an AOM/DSS regimen. This study represents the first scRNA-seq assessment of tumors formed in DPEP1 KO mice

ORGANISM(S): Mus musculus

PROVIDER: GSE290572 | GEO | 2025/03/15

REPOSITORIES: GEO

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Ablation of S1PR4 triggers CD8+ T cell expansion to reduce tumor growth and improve therapy

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Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer

Project description:Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer

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AOM/DSS tumors 5FU+Irinotecan treatment

Project description:AOM/DSS tumors 5FU+Irinotecan treatment

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