Spatial Transcriptome Profiling Reveals Molecular Features of Invasive Lobular Carcinoma in Breast Cancer.

ABSTRACT: These samples were collected for spatial transcriptome analysis of invasive lobular carcinoma of the breast (ILC). We analyzed differences in the molecular profiles of classical ILCs (C-ILCs) and polymorphic ILCs (P-ILCs). We obtained transcriptome data from ● different spots. The cell type of each spot was inferred from copy number changes and gene expression data of human tumors by SpaCET. There were 11 cell types, with cancer-dominant and CAF-dominant spots accounting for the majority. Analysis of canonical pathways and upstream regulators by IPA indicated that the cell cycle is upregulated in P-ILC cancer-dominant spots than in C-ILC cancer-dominant spots. Furthermore, EMT and angiogenesis were upregulated in P-ILC stroma-dominant spots than in C-ILC stroma-dominant spots.

ORGANISM(S): Homo sapiens

PROVIDER: GSE290670 | GEO | 2026/03/31

REPOSITORIES: GEO