A novel human heart-derived natural adeno-associated virus capsid combines cardiospecificity with cardiotropism in vivo

ABSTRACT: Adeno-associated virus serotype 9 (AAV9) is currently considered the benchmark vector for clinical cardiac gene transfer applications but can entail severe hepatotoxicity due to its strong hepatotropism. Against this background, we report the discovery of a novel AAV capsid (cap) isolated from human myocardium that uniquely combines cardiospecificity with cardiotropism in vivo and bears potential to impact future cardiac gene therapy developments.

ORGANISM(S): Mus musculus

PROVIDER: GSE290777 | GEO | 2025/05/07

REPOSITORIES: GEO