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Effect of anti-IL-4 and anti-IL-13 vaccination in a mouse model of atopic dermatitis

ABSTRACT: The effect of anti-mouse IL-4 and/or anti-mouse IL-13 Kinoid vaccines was assessed in a model of atopic dermatitis. Mice were immunized with IL-4 and/or IL13 Kinoids (or the carrier protein CRM197 alone as control). Atopic dermatitis-like pathology was induced by repeated epicutaneous exposures to house dust mite and the enterotoxin B from Staphylococcus aureus (SEB). Lesional skin biopsies were collected for bulk RNA sequencing analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE290968 | GEO | 2025/12/10

REPOSITORIES: GEO

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