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Keratinocyte-secreted SAA1 induces a population of long-lived antigen-presenting neutrophils that drives Sweet Syndrome

ABSTRACT: Sweet syndrome (also known as acute febrile neutrophilic dermatosis), is a rare inflammatory skin disorder characterized by erythematous plaques with a dense dermal neutrophilic infiltrate. It remains unknown how neutrophils, which are generally short-lived, persist in the skin of patients with Sweet syndrome. We report that Sweet syndrome skin contains a unique population of long-lived antigen-presenting cell (APC)-neutrophils that are not present in blood or unaffected skin.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291004 | GEO | 2025/08/12

REPOSITORIES: GEO

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