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Serotonin activates dermal papilla cells and promotes hair growth

ABSTRACT: We examined effects of serotonin (5HT) or sumatriptan on the hair growth ability of dermal papilla cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291220 | GEO | 2025/07/16

REPOSITORIES: GEO

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Serotonin activates dermal papilla cells and promotes hair growth

Project description:Serotonin activates dermal papilla cells and promotes hair growth

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Global profiling of human hair follicle scalp dermal papilla cells using Affymetrix microarrays

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Project description:Different types of hair follicles can be found in the skin of mice. It is believed that the signals that control hair follicle differentiation arise from cells in a structure called the dermal papilla. Understanding the nature of those signals is of interest for the biology of the normal tissue. We have developed a technique for isolation of dermal cells by enzymatic digestion of intact skin. We have identified two subpopulations of cells that can be separated by FACS. The Sox2-positive CD133-positive cells are found exclusively in the dermal papillae of guard/awl/auchene hairs, while Sox2-negative, CD133-positive cells are found in the other hair follicle types. We compared these populations with unfractionated dermal cells. We isolated the following 3 populations of cells from the back skin of neonatal mice (P2) by Flow Cytometry: 1) GFP-CD133- Total dermal cells 2) GFP-CD133+ Dermal Papilla cells 3) GFP+CD133+ Dermal Papilla cells The yield is approximately 50,000 cells of each population.

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