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An epigenomic investigation of DNA methylation levels in matched left- and right- atrial fibrillation human cohort

ABSTRACT: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, approximately affecting 2% of individuals worldwide with recent epidemiological reports expecting cases to double over the next two decades. Currently, there is a critical need to improve prevention and clinical management of AF patients. Recent genome-wide association studies have revealed over 150 genetic loci associated to AF susceptibility, the majority of which reside within non-coding portions of the human genome, suggesting they are involved in gene regulatory processes. To investigate patient-specific epigenomic changes in AF, we employed epigenomic approaches across a set of patient atrial samples and sinus rhythm controls, comprising paired left and right atrial tissue. Here, we report profiling of DNA methylation levels, which we integrated with histone modification data and matched gene expression profiles. Interestingly, we identified AF-specific epigenomic regions associating with concordant gene expression and methylation patterns pointing to novel candidate disease loci. Additionally, we further validated candidate regions of interest in an independent cohort using quantitative PCR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291249 | GEO | 2026/02/16

REPOSITORIES: GEO

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