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Variant Polycomb Repressive complexes 1 (vPRC1s) in synovial sarcoma

ABSTRACT: Several variant Polycomb Repressive complexes 1 (vPRC1s) co-exist to robustly deposit mono ubiquitination on histone H2A (H2AK119ub1). Their interconnected roles and specific tasks across normal and disease cellular states remain unclear. In synovial sarcoma (SS), a soft tissue tumor driven by the oncogenic fusion protein, SS18::SSX, the SSX tail exhibits a high affinity to H2AK119ub1 marked genomic regions. This mechanism is crucial to sequester the mSWI/SNF complex to PRC1 targets and results in their aberrant expression. We previously showed that PRC1.1 is responsible for H2AK119ub1 deposition in SS and is therefore required for SS18::SSX occupancy. Here, we investigated the role of PRC1 variants in synovial sarcoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291441 | GEO | 2025/03/17

REPOSITORIES: GEO

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