N6-Methyladenosine-Modified circPICALM Encodes a Protein That Promotes Intrahepatic Cholangiocarcinoma Metastasis

ABSTRACT: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive primary liver cancer characterized by rapid progression and strong metastatic potential. Circular RNAs (circRNAs) are emerging as crucial regulators in the complex biology of cancer, yet their specific roles in ICC metastasis remain poorly defined. In this study, circRNA sequencing of paired primary and recurrent ICC tissues revealed that elevated expression of circRNA PICALM (circPICALM) is strongly linked to ICC metastasis and patient prognosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291554 | GEO | 2026/04/15

REPOSITORIES: GEO