Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cellular and molecular evolutionary mechanisms of retinal cells governing color vision perception

ABSTRACT: Insights into the cellular and molecular evolutionary mechanisms of retinal cells that govern color vision perception across various species are limited. In this study, we established a single-cell prediction (scPred) model to construct an atlas of single-cell retinas from multiple species and subsequently analyzed interspecies variations in the retinal cells of 24 different species. We identified conserved compositions and expression profiles of retinal cells, with photoreceptor cells, including rods, showing dynamic changes from lower to higher species. Moreover, we observed marked interspecies variations in opsin expression patterns and core transcriptional programs that regulate color vision in rods and cones. We also identified distinct cell metabolism patterns and key transcription factors influencing the cell functional difference of different cone types. Notably, our findings indicated an association between fatty acid biosynthesis and OPN1SW+ cones and OPN1MW+ cones, as well as an association between FOXO3 and OPN1LW+ cones across species.

ORGANISM(S): Channa argus Oreochromis Gallus gallus Anas platyrhynchos Melopsittacus undulatus Felis catus

PROVIDER: GSE291611 | GEO | 2025/09/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cellular and molecular evolutionary mechanisms of retinal cells governing color vision perception

Project description:Insights into the cellular and molecular evolutionary mechanisms of retinal cells that govern color vision perception across various species are limited. In this study, we established a single-cell prediction (scPred) model to construct an atlas of single-cell retinas from multiple species and subsequently analyzed interspecies variations in the retinal cells of 24 different species. We identified conserved compositions and expression profiles of retinal cells, with photoreceptor cells, including rods, showing dynamic changes from lower to higher species. Moreover, we observed marked interspecies variations in opsin expression patterns and core transcriptional programs that regulate color vision in rods and cones. We also identified distinct cell metabolism patterns and key transcription factors influencing the cell functional difference of different cone types. Notably, our findings indicated an association between fatty acid biosynthesis and OPN1SW+ cones and OPN1MW+ cones, as well as an association between FOXO3 and OPN1LW+ cones across species.

2025-09-02 | GSE266415 | GEO

Recruitment of Rod Photoreceptors from Short Wavelength Sensitive Cones during the Evolution of Nocturnal Vision in Mammals

Project description:Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase early in their evolution. We investigated the evolutionary and developmental origins of rods in two divergent vertebrate retinae. In mice, we discovered genetic and epigenetic vestiges of short wavelength cones in developing rods and cell lineage tracing validated the genesis of rods from S-cones. Curiously, rods did not derive from S-cones in zebrafish. Our study illuminates several questions regarding the evolution of duplex retina and supports the hypothesis that, in mammals, the S-cone lineage was recruited via the Maf-family transcription factor NRL to augment rod photoreceptors. We propose that this developmental mechanism allowed the adaptive exploitation of scotopic niches during the nocturnal bottleneck early in mammalian evolution.

2016-06-21 | GSE81953 | GEO

Recruitment of Rod Photoreceptors from Short Wavelength Sensitive Cones during the Evolution of Nocturnal Vision in Mammals

2016-06-21 | GSE74660 | GEO

Recruitment of Rod Photoreceptors from Short Wavelength Sensitive Cones during the Evolution of Nocturnal Vision in Mammals

2016-06-21 | GSE81099 | GEO

HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice

Project description:Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of accurate and color vision and ultimately blindness. In RP, a vast number of mutations are affecting the structure and function of rod photoreceptors while cones remain mutation-free. Once majority of rods have degenerated cones are dying secondarily due to the increased oxidative stress, inflammation and loss of structural and nutritional support normally provided by rods. Here we demonstrated that secondary cone cell death in animal models for RP is governed by an increased activity of histone deacetylates (HDACs). A single intravitreal injection of an HDAC inhibitor at a late stage of the disease, when majority of rods have already degenerated, is sufficient to delay cone death and support long-term cone survival. Surviving cones are retaining functionality and are mediating light-driven ganglion cell responses. RNA-seq analysis of surviving cones demonstrated that HDAC inhibition affords multi-level protection trough regulation of different prosurvival pathways including MAPK, PI3K-AKT and autophagy. These study suggest a unique possibility for targeted pharmacological protection of both primary degenerating rods and mutation-free secondary dying cones and creates hope to maintain vision in RP patients independent of the disease stage.

2020-11-04 | GSE141601 | GEO

Generation, transcriptome profiling, and functional validation of cone-enriched human retinal organoids

Project description:The macula of the retina has a high ratio of cones to rods and is critical for central vision and visual acuity. Macula degenerations affect vision the most and are incurable. Here we report the generation, transcriptome profiling, and functional validation of cone-enriched human retinal organoids differentiated from hESCs. Transcriptome profiling using bulk RNA-seq demonstrated that retinal differentiation in vitro recapitulated retinogenesis in vivo in the temporal expression of cell differentiation markers and retinal disease genes, as well as in mRNA alternative splicing. Single-cell RNA-seq of 8-month retinal organoids identified clusters of cone and rod photoreceptors and confirmed the cone enrichment initially revealed by immunostaining. Notably, comparisons of single-cell transcriptomes demonstrated the similarity between retinal organoids and human macula in cones and rods. Cones in retinal organoids exhibited electrophysiological functions. Collectively, we have established cone-enriched retinal organoids and a reference of transcriptomes that are rich resources for retinal studies.

2019-04-25 | GSE119274 | GEO

Samd7 preserves cell identity and enforces the ‘one neuron-one receptor’ rule in vertebrate photoreceptors [5dpf_td]

Project description:The exclusive expression of single sensory receptors in individual neurons (the ‘one-neuron-one receptor’ rule) is essential for vision and other sensory systems. Here, we show that the transcriptional corepressor Samd7 enforces this rule in vertebrate red cones and acts in other photoreceptor types to maintain cell identity. In the zebrafish samd7-/- retina, red cones are transformed to hybrid red/UV-sensitive cones, green cones are transfated to blue cones, and the number of rods is greatly reduced. In the mouse Samd7-/- retina, dorsal M-cones are transformed to hybrid M/S-cones—analogous to the transformation of red to red/UV cones that occurs in zebrafish—and rods aberrantly express cone genes including S-opsin. Altogether, Samd7 acts to repress short-wavelength cone gene expression in long-wavelength-sensitive cones, thereby sustaining the mutually exclusive patterns of opsin expression and cone identity required for color vision.

2024-06-21 | GSE249755 | GEO

Samd7 preserves cell identity and enforces the ‘one neuron-one receptor’ rule in vertebrate photoreceptors [adult]

2024-06-21 | GSE249754 | GEO

Samd7 preserves cell identity and enforces the ‘one neuron-one receptor’ rule in vertebrate photoreceptors [5dpf_whole_eye]

2024-06-21 | GSE249751 | GEO

Samd7 preserves cell identity and enforces the ‘one neuron-one receptor’ rule in vertebrate photoreceptors

2024-06-21 | GSE269667 | GEO