PLCG2 modulates TREM2 expression and signaling in response to Alzheimer’s disease pathology 

ABSTRACT: Phospholipase C gamma 2 (PLCG2) is an intracellular effector of microglial cell surface receptors, including TREM2. Variants which alter PLCG2 activity impact Alzheimer’s disease (AD) risk, but the effects of PLCG2 deficiency in AD remain unclear.

ORGANISM(S): Mus musculus

PROVIDER: GSE291648 | GEO | 2025/05/14

REPOSITORIES: GEO