2p Gain-Driven REL Overexpression Confers Resistance to BTK Inhibitors in Chronic Lymphocytic Leukemia

ABSTRACT: Gain of the short arm of chromosome 2 (2p) is a frequent chromosomal abnormality in advanced Chronic Lymphocytic Leukemia (CLL), but how it contributes to CLL pathogenesis and progression is still poorly understood. Using a multiparameter approach that combines scRNA sequencing, cellular biology on primary CLL cells and engineered cell lines, as well as clinical analyses, our data show that 2p gain leads to NF-kB activation through REL overexpression, thereby contributing to BTKi resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE292026 | GEO | 2025/12/29

REPOSITORIES: GEO