Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast phase MPN through targetable overexpression of DYRK1A

ABSTRACT: To investigate the effect of chr21amp on cell differentiation, we performed droplet-based, high-throughput single-cell RNA-seq on Lin-CD34+ cells and total mononuclear cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE292030 | GEO | 2025/03/27

REPOSITORIES: GEO