Genetic deletion of RUNX1 or RUNX2 in adipocytes enhanced beige fat formation

ABSTRACT: RUNX1/2 overexpression suppresses critical functions associated with brown adipocyte biology, particularly thermogenesis and cellular respiration. Conversely, deletion of RUNX1 or RUNX2 led to a significant increase in cellular temperature, with DKO cells showing the greatest temperature increase.These findings indicate that RUNX1/2 act as negative regulators of thermogenic adipocyte differentiation and actively suppress the thermogenic gene program and function.

ORGANISM(S): Mus musculus

PROVIDER: GSE292084 | GEO | 2026/02/12

REPOSITORIES: GEO