Targeting YAP-Hhip mediated osteogenesis in Gli1+ osteogenic progenitors suppresses aberrant subchondral bone remodeling in osteoarthritis

ABSTRACT: Our findings demonstrated that YAP plays a critical role in subchondral bone remodeling. Furthermore, targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression. This may offer new therapeutic insights for treating OA.

ORGANISM(S): Mus musculus

PROVIDER: GSE292170 | GEO | 2026/01/01

REPOSITORIES: GEO