RNA-seq of ME-HESC in SRF-deficient vs Normal Conditions

ABSTRACT: The transcription factor SRF plays known roles in mitogenic cell response and muscle cell development, and potential roles in endometrial stromal decidualization have been reported. After RNAi-based SRF knockdown in menstrual effluent-derived primary human endometrial stromal cells (ME-HESC), SRF-deficient cells exhibited disrupted cytoskeletal remodeling, cell cycle, and extracellular matrix genes. These data show that SRF is important for endometrial stromal cell homeostasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE292411 | GEO | 2025/09/30

REPOSITORIES: GEO