Radon Exposure Delays the Development of Skin Lesions in a Mouse Model of Psoriasis

ABSTRACT: We used transgenic mice that spontaneously develop chronic psoriatic skin lesions inflicted (CD11c-IL-17Aind/ind mice) to investigate effects induced by multiple radon exposures. Comprehensive transcriptome profiling of non-lesional skin showed downregulation of genes associated with psoriasis initiation, while anti-inflammatory genes were upregulated. Pathway enrichment analysis revealed immunosuppressive effects related to T cell regulation, similar to UV radiation-induced response.

ORGANISM(S): Mus musculus

PROVIDER: GSE292505 | GEO | 2025/11/04

REPOSITORIES: GEO