Single-Cell Transcriptome Profiling of PBMCs in Response to Diverse Immune Adjuvant Stimuli

ABSTRACT: Immune adjuvants are agents that enhance the immunogenicity of vaccines when co-administered with antigens. While their primary mode of action involves activation of innate immune pathways in antigen-presenting cells such as myeloid cells—leading to cellular maturation and enhanced antigen presentation—how adjuvants affect other hematopoietic cell types remains largely unclear. To address this, we performed single-cell RNA sequencing of human PBMCs treated with various immune adjuvants, aiming to characterize cell type–specific transcriptional responses at single-cell resolution.

ORGANISM(S): Homo sapiens

PROVIDER: GSE292981 | GEO | 2025/12/31

REPOSITORIES: GEO