Transcriptomic comparison of hepatocytes derived from a panel of human induced pluripotent stem cells with different ethnicities

ABSTRACT: In the current study, we attempted to establish an in vitro model for assessing population variability in hepatotoxicity testing using a panel of hepatocytes derived from nine human induced pluripotent stem cell (iPSC) lines belonging to three different ethnic groups, Black or African American (BAA), Latino or Hispanic (LOH), and Non-Hispanic White (NHW). The panel of iPSC-derived hepatocytes were exposed to diglycolic acid (DGA) and usnic acid (UA), and transcriptomic changes were characterized and compared.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293032 | GEO | 2025/04/21

REPOSITORIES: GEO