Evolutionary transcriptomic and cellular specializations within the mammalian striatum

ABSTRACT: In this study we generated and analyzed single-nucleus RNA sequencing (snRNA-seq) of human, chimpanzee, rhesus macaque (this study and GSE167920), marmoset (GSE151761 and GSE165578), bat caudate (CN) and putamen (Pu) separately, ferret caudate (GSE151761), and mouse caudoputamen (C-Pu)(GSE151761) spanning 94 million years of evolution. We identified novel interneuron cell types in bat Pu while uncovering fundamental cellular compositional and transcriptomic differences between primate and non-primate striata.

ORGANISM(S): Phyllostomus discolor Pan troglodytes Homo sapiens Macaca mulatta

PROVIDER: GSE293075 | GEO | 2026/03/27

REPOSITORIES: GEO