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The role of Treg-mediated IL-6R signaling in epithelial cell biology

ABSTRACT: IL-6 has been shown to be crucial in promoting inflammation in the context of IBD. Our previous work demonstrated an impairment of the FOXP3-mediated interactions necessary for Tregs to suppress immune responses following incubation with IL-6. However, the precise role of IL-6 and its receptor (IL-6R) signaling in Tregs and the impact on other cell types during IBD pathogenesis remains to be studied. Here we demonstrate that loss of the IL-6R on Tregs negatively impacts intestinal epithelial cell homeostasis, and suggests the alterations could be contributing to an exacerbated phenotype in an in vivo model of colitis.

ORGANISM(S): Mus musculus

PROVIDER: GSE293157 | GEO | 2025/12/31

REPOSITORIES: GEO

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	GSE293157_GEO_expression.tsv.gz	Tabular

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