A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immuno-therapy

ABSTRACT: Single-cell RNA-seq analysis of bioengineered human bone marrow leukemia chip established with human B-ALL cells (REH, ATCC), Human umbilical vein cells (HUVECs, Lonza), Human mesenchymal stem cells (hMSC, Lonza), Human Bone marrow mononuclear cells (STEMCELL Technologies), and Human MSC osteoblasts (Lonza) using the reported Leukemia-on-a-Chip method treated with Healthy donor derived CAR Tcells, Patient derived CAR T cells, Mock T cells, and or left non-treated.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293390 | GEO | 2025/04/29

REPOSITORIES: GEO