Single cell resolution of an open chromatin signature in persister tumor cells

ABSTRACT: To characterize transcriptional and chromatin accessibility changes that promote survival of residual cancer following chemotherapy, we performed single-cell multiomic profiling (snRNA+snATAC) on a cohort of non-malignant fallopian tube, treatment-naive, and neoadjuvant chemotherapy (NACT)-treated high-grade serous ovarian cancer (HGSOC) samples. From this analysis, we identified an epigenetic signature that precedes expression and defines the drug-tolerant persister state.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293459 | GEO | 2025/11/13

REPOSITORIES: GEO