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Unraveling the role of ATOH8 in trophoblast lineage differentiation

ABSTRACT: Extravillous trophoblasts (EVTs) play a vital role in placental development by anchoring the placenta to the uterine wall, invading the maternal decidua, and remodeling maternal spiral arteries. ATOH8, a basic helix-loop-helix (bHLH) transcription factor, is central to regulating trophoblast dynamics at the maternal-fetal interface, where it orchestrates their invasive potential, proliferative capacity, and differentiation in mice. By coordinating these processes, ATOH8 ensures the formation of a functional placental structure critical for sustaining pregnancy. Although ATOH8 has been implicated in decidualization—a key preparatory event in human endometrial stromal fibroblasts essential for placental development, its precise mechanisms and contributions to human trophoblast function remain unresolved. To understand the role of ATOH8 in EVT differentiation, we performed RNA sequencing of ATOH8-depleted EVT and control EVT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293496 | GEO | 2025/12/04

REPOSITORIES: GEO

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