Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

EV miRNA Profiles from Nipple Discharge, Intracystic Fluid, and Tumor Tissue Surface in Breast Cancer

ABSTRACT: Breast cancer is the most common cancer among women worldwide, and nipple discharge (ND) is one of its major symptoms. In this study, we investigated extracellular vesicles (EVs) in ND as potential biomarkers. We developed novel EV collection methods using cellulose nanofiber (CNF) sheets, which capture EVs within the porous nanopaper and require only 10 microliters of liquid (Yokoi A, et al. Nat Commun. 2023;14(1):6915).

ORGANISM(S): Homo sapiens

PROVIDER: GSE293809 | GEO | 2026/06/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Real-time quantitative PCR analysis of human EMT genes in MCF-7 cells [Data S8]

Project description:Human EMT PCR array PCR array data for expression of EMT genes in MCF-7 cells after treating with ND and T2D adipocytes EVs.

2021-10-22 | GSE186366 | GEO

Nipple fibroblast gene expression profile

Project description:The nipple is an example of specialized epidermis. The unique epidermal stratification and gene expression is induced and maintained by developmental distinct fibroblast populations. To identify specific signaling modules involved in the maintenance of nipple epidermis we used gene expression profiling of purified fibroblast populations from a murine model of nipple skin formation

2017-03-13 | GSE87030 | GEO

Distinct transcriptional profiles in the different phenotypes of neurofibroma from the same neurofibromatosis 1 subject

Project description:Background: Neurofibromatosis 1 (NF1) is one of the most common hereditary neurocutaneous disorders. Among clinical phenotypes of NF1, cutaneous neurofibroma (cNF) and plexiform neurofibroma (pNF) display distinct clinical manifestations and pNF should be carefully followed up due to its potential for malignant transformation. However, the detailed distinct features of pNF compared to the other phenotypes in NF1 remains unclear. Objective: To elucidate whether transcriptional features are altered between cNF and pNF within the same patient. Methods: Single-cell RNA-sequencing was performed on the isolated cNF and pNF cells from the same patient. Immunohistochemical analysis was conducted on 6 cNF and 5 pNF specimens from different subjects. Results: cNF and pNF have different microenvironment and distinct transcriptional profiles. Schwann cells with robust metabolic capacity and fibroblasts with cancer-associated fibroblast-like phenotype are enriched in pNF, while CD8 T cells with tissue residency markers are endowed in cNF. The density of CD8 T cells is histologically augmented in cNF. Conclusion: cNF and pNF, the different NF phenotypes in NF1, are transcriptionally distinct in terms of various involved cell types including immune cells.

2023-09-30 | GSE218493 | GEO

Real-time quantitative PCR analysis of human EMT genes in MCF-7 cells [Data S9]

Project description:Human EMT PCR array PCR array data for expression of Cancer Stem Cell (CSC) genes in MCF-7 cells after treating with ND and T2D adipocytes EVs.

2021-10-22 | GSE186431 | GEO

High fat diet inhibits EV-Mediated angiogenisis

Project description:Mesenchymal stem cell-derived extracellular vesicles (EVs) have been shown to promote angiogenesis in the ischemic myocardium. This study examines the difference in vascular density, myocardial perfusion, molecular signaling, and gene expression between normal diet (ND) and high fat diet (HFD) groups at baseline and following intra-myocardial injection of EVs We used GeneChip Gene Arrays for whole-transcriptome analysis between normal diet and high fat diet groups at baseline and following intra-myocardial injection of Evs.

2020-07-09 | GSE154028 | GEO

Human Neurofibroma Matrisome Revealed by Single Cell RNA Sequencing

Project description:This study revealed the type of ECM secreted by each cell type, provided a complete profiling of cNF collagen, and identified specific cNF fibroblast markers that will provide a molecular platform to further explore the biology of cutaneous neurofibroma

2021-01-15 | GSE163028 | GEO

EV miRNA Profiles from Nipple Discharge, Intracystic Fluid, and Tumor Tissue Surface in Breast Cancer

Project description:EV miRNA Profiles from Nipple Discharge, Intracystic Fluid, and Tumor Tissue Surface in Breast Cancer

| PRJNA1246419 | ENA

human metagenome

Project description:Nipple Aspirate Fluid Microbiome

| PRJNA314877 | ENA

Genome-wide DNA methylation profiling of cell-free DNA in nipple aspirate fluid for breast cancer

Project description:Nipple aspriate fluid (NAF) were obtained from 7 women including 3 breast cancer patients. Cell-free DNA (cfDNA) were isolated and bisulfite sequencing using Illumina HiSeq X Ten platform.

2023-09-26 | GSE238014 | GEO

Unraveling the Development of Cutaneous Neurofibromas in Neurofibromatosis Type 1

Project description:Neurofibromatosis type 1 (NF1) is a genetic disorder that leads to the formation of cutaneous neurofibromas (cNFs), benign nerve sheath tumors that develop in the skin and significantly impact patients’ quality of life. cNF development begins with bi-allelic NF1 loss in Schwann cell (SC) lineage, followed by the recruitment of a complex tumor microenvironment consisting of fibroblasts, immune cells, blood vessels, axons and a dense extracellular matrix. Despite their high prevalence and clinical impact, the molecular mechanisms underlying cNF formation remain poorly understood. Here, we used an Nf1 knockout (Nf1-KO) mouse model, combined with immuno-histochemistry and single-cell transcriptomics, to explore the mechanisms driving cNF development. Our findings revealed that mutant SCs accumulate in the skin of young mice weeks before cNF onset. However, these cells remain quiescent until triggered by skin trauma, which induces their proliferation and the rapid formation of cNFs. Using a trauma-induced Nf1-KO model with scRNAseq, we conceived a transcriptomic atlas of growing and mature cNFs, as well as adjacent, seemingly healthy skin. This analysis identified a population of non-myelinating Aquaporin1highNestinlow SCs as the likely cells of origin for cNFs. These cells overexpress genes involved in axon growth and guidance, potentially driving the abnormal innervation observed in cNFs from both mice and patients. Additionally, we found that tumor SCs, along with dermal and/or epineurial fibroblasts and pericytes, overexpress collagen-encoding genes, contributing to the extensive fibrosis characteristic of cNFs. Notably, all of these cells exhibit high expression of Periostin and Tenascin C, key extracellular matrix components, highlighting them as novel therapeutic targets for cNF treatment.

2025-07-23 | GSE289794 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data