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Transcriptomic analysis reveals jejunal mechanisms underlying postbiotic mediated immune systems in calves

ABSTRACT: This study aimed to investigate the effect of dietary supplementation with postbiotic from dead cell Lactobacillus ingluviei CR37 (DCLI) on blood biochemical parameters, and jejunal epithelium transcriptomic profiles in calves. Transcriptomic analysis identified 76 DEGs, with significant upregulation of genes involved in fatty acid metabolism (FABP1), intestinal barrier function (B4GALNT2), and detoxification (GSTA1), alongside downregulation of immune response regulation (FCRLA, FCRL4). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses highlighted enrichment in pathways related to Glutathione metabolism, Drug metabolism, and Vitamin digestion, indicating postbiotic supplementation improved detoxification, oxidative stress defense, and nutrient absorption in calves. This study provides novel insights into the molecular mechanisms underlying the benefits of postbiotics and supports their potential as a sustainable alternative to probiotics in calf nutrition

ORGANISM(S): Bos taurus

PROVIDER: GSE293812 | GEO | 2025/04/10

REPOSITORIES: GEO

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