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The impact of SOGA1 deficiency on gene expression in ovarian cancer cells

ABSTRACT: SOGA1 is an autophagy-related factor that significantly influences cancer progression.Here, we identified the critical role of SOGA1 in the diagnosis and prognosis of ovarian cancer through bioinformatics analysis.Further functional experiments demonstrated that SOGA1 significantly promotes ovarian cancer progression through GNAI1.RNA-seq analysis revealed that differentially expressed genes downstream of SOGA1 are significantly enriched in the TNF signaling pathway, which was validated by Western blot.In summary, our data provide new molecular insights into ovarian cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293833 | GEO | 2026/04/10

REPOSITORIES: GEO

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