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Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

ABSTRACT: To examine transcriptional plasticity in sensory neurons, we performed bulk RNA-sequencing studies on dorsal root ganglia from an atopic dermatitis-like mouse and a contact dermatitis monkey model.

ORGANISM(S): Mus musculus Macaca nemestrina

PROVIDER: GSE293900 | GEO | 2025/08/06

REPOSITORIES: GEO

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Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

Project description:Upregulated Natriuretic Peptide B expression as a hallmark of chronic itch

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Project description:Introduction: The interaction between the nervous and immune systems is crucial for maintaining homeostasis and can influence disease progression in inflammatory skin diseases, such as atopic dermatitis (AD). Sensory neurons in the skin can secrete neuropeptides that modulate immune cell activity, including Langerhans cells (LCs), the primary antigen-presenting cells in the epidermis. This study investigates the effects of neuropeptides on the differentiation of monocyte-derived LCs (moLCs), specifically the neuropeptides with the most profound effect, i.e. atrial- and B-type natriuretic peptides (ANP and BNP, respectively).

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Project description:In order to analyze the regulatory effects of UII and GPR14 on gene transcription in Mc903-induced atopic dermatitis skin, ear skin collected from MC903 chronic itch mouse model on day 13 was used for in-depth analysis and sequencing of skin gene expression. The effect of GSK1562590 on the expression of pruritus and inflammatory factors in dermatitis was detected by RNA-seq.

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