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CUT&RUN sequencing - E12 mouse embryonic cortices ZBTB7A - GATAD2B - H3K27ac…

ABSTRACT: These are CUT&RUN analyses performed with embryonic day 12 (E12) CD1 mouse neocortices. Targets were ZBTB7A, GATAD2B, H3K4Me3, H3K4Me1, H3K27Ac, and IgG control.

ORGANISM(S): Mus musculus

PROVIDER: GSE294107 | GEO | 2025/04/09

REPOSITORIES: GEO

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CUT&RUN sequencing - E12 mouse embryonic cortices ZBTB7A - GATAD2B - H3K27ac…

Project description:CUT&RUN sequencing - E12 mouse embryonic cortices ZBTB7A - GATAD2B - H3K27ac…

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RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cKO vs WT

Project description:This is RNA sequencing performed with embryonic day 12 (E12) microdissected mouse cortices with the following genotypes: Emx1 Cre/ +; Zbtb7a +/+ (WT) and Emx1 Cre/+; Zbtb7a fl/fl (cKO). The goal of this study was to understand the impact ot Zbtb7a knockout during cortical development.

2025-04-09 | GSE294144 | GEO

RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cHet vs cKO vs WT

Project description:This is RNA sequencing performed with embryonic day 12 (E12) microdissected mouse cortices with the following genotypes: Emx1 Cre/ +; Zbtb7a +/+ (WT), Emx1 Cre/+; Zbtb7a fl/+ (cHet) and Emx1 Cre/+; Zbtb7a fl/fl (cKO). The goal of this study was to understand the impact ot Zbtb7a knockout during cortical development.

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RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cKO vs WT

Project description:RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cKO vs WT

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RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cHet vs cKO vs WT

Project description:RNA sequencing - E12 mouse embryonic cortices Emx1-Cre Zbtb7a-flox cHet vs cKO vs WT

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ZBTB7A ChIP-seq under different DHT level

Project description:Zinc finger and BTB domain containing transcription repressor ZBTB7A has been recently reported as a tumor suppressor who plays important functions to prevent the progression of prostate cancer. However, the chromatin activity of ZBTB7A in prostate cancer cells remain unclear. In order to identify the cistrome and transcriptome of ZBTB7A, we performed ZBTB7A ChIP-seq in VCaP cells and RNA-seq in VCaP cells transfected with siRNA targeting ZBTB7A or non-targeting control, respectively (cells were grown in full serum). By using combined ChIP-seq and RNA-seq analyses in VCaP cells, we have precisely mapped the ZBTB7A binding sites and identified a subset of genes that are directly repressed by ZBTB7A. To study the chromatin interaction of ZBTB7A with androgen receptor (AR), we also performed ChIP-seq of ZBTB7A in VCaP cells stimulated with 10 nM DHT for 4 hours versus vehicle control (cells were hormone-depleted prior to DHT stimulation). Our results show that ZBTB7A binding is increased by androgen at AR and ZBTB7A overlapping sites.

2019-09-12 | GSE123089 | GEO

RNA-seq with knockdown ZBTB7A and NTC control

2019-09-12 | GSE123090 | GEO

Transcriptome of mouse E12 neocortex

Project description:Transcriptome of mouse E12 neocortex

2023-04-27 | GSE149491 | GEO

Transcription factor ZBTB7A-deficiency effect on U87MG cells in vitro

Project description:Analysis of glioblastoma cell line U87MG depleted for ZBTB7A (Zinc Finger and BTB Domain Containing 7A, also known as FBI1, POKEMON or LRF). ZBTB7A is transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Results provide insight into the role of ZBTB7A in glioblastoma.

2023-02-08 | GSE196320 | GEO

Trancriptome sequencing of BGC823 with or without ZBTB7A knockdown

Project description:Tumor budding (TB), clusters of less than 5 cells dissociated from the tumor mass, is reported to predict nodal involvement and recurrence in multiple human cancers including gastric carcinoma (GC). However, it is not clear how TB forms. In this study, we determined the expression pattern of GAGE12I, CTNND1, Kif26B, CREB1 and ZBTB7A in human GC samples by IHC attempting to find any TB-related markers. The results showed that TB could predict lymph node metastasis and is negatively associated with the overall survival of GC patients. The expression of ZBTB7A in the tumor margin (invasive front), rather than the other four markers, was much higher than that inside the tumor and was positively correlated with TB score. Moreover, patients with higher marginal ZBTB7A expression had poorer prognosis. ZBTB7A could enhance the migration and invasion capabilities of GC cells in vitro. Mechanically, ZBTB7A might activate EGFR-MAPK-ERK and PI3K-AKT-mTOR pathway, which resulted in epithelial-mesenchymal transition (EMT) to induce the formation of TB. Thus, we concluded that higher ZBTB7A expression in the tumor margin may contribute to the dissociation of tumor cells from the tumor mass to form TB by initiating EMT via EGFR-MEK-ERK and PI3K-AKT-mTOR pathway.

2020-12-31 | GSE147199 | GEO

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