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Modulation of growth and angiogenesis of OSCC cells with Sal B

ABSTRACT: In this study we used in vitro approaches to investigate whether it has any inhibitory properties on OSCC cells. We also tried to understand the possible mechanisms of Sal B on this type of malignancy with respect to angiogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE29416 | GEO | 2011/05/21

SECONDARY ACCESSION(S): PRJNA141521

REPOSITORIES: GEO

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Modulation of growth and angiogenesis of OSCC cells with Sal B

Project description:In this study we used in vitro approaches to investigate whether it has any inhibitory properties on OSCC cells. We also tried to understand the possible mechanisms of Sal B on this type of malignancy with respect to angiogenesis. 2 OSCC cell lines were treated with 100ug/ml Sal B for 48hours. cDNAmicroarray was used to evaluated the expressions of 96 genes known to be involving in modulating the biological process of angiogenesis.

2011-05-21 | E-GEOD-29416 | biostudies-arrayexpress

Modulation of growth and angiogenesis of OSCC cells with Sal B

Project description: Not available

| S-ECPF-GEOD-29416 | biostudies-other

Lactobacillus sp. SAL.1 isolate:SAL.1

Project description:Lactobacillus sp. SAL.1 isolate:SAL.1 Genome sequencing

| PRJNA634427 | ENA

Protein markers in Oral Squamous Cell Carcinoma (OSCC)

Project description:Oral squamous cell carcinoma (OSCC) is a main reason of oral cancer mortality and morbidity. Cancer of oral cavity in central south Asia, ranks among third most common kinds of cancer. The discovery of candidate markers to differentiate normal from malignant cells in clinical diagnosis of OSCC would be of critical importance because this malignancy has poor prognosis. To improve the clinical outcome in OSCC patients, the present study was aimed at identifying robust candidate biomarkers for early OSCC diagnosis and to enhance understanding of the mechanisms of disease progression and pathogenesis. Of particular interest are proteins that can be found in tissue lysates of OSCC tumor vs normal adjacent mucosa samples and secreted in cell line Secretomes of HNSCC for non-invasive detection. We analysed 17 paired human malignant OSCC tissues and normal adjacent tissue in addition to secretomes of 9 HNSCC cell lines. The proteome dataset of OSCC and normal tissues consisted of 5,123 protein groups, including 299 proteins with strong differential expression (p-value <0.01, fold change barrier to ˃+2 and <-2, 205 upregulated and 94 down regulated) and 134 common proteins were also found out of total dataset of 4473 identified proteins of HNSCC cell line secretomes. Functional data analysis revealed that these differential proteins were significantly associated with multiple biological processes. Myogenesis, Fatty Acid Metabolism and KRAS Signaling DN were associated with the proteins downregulated in cancer tissues, while Protein Secretion, Unfolded Protein Response, Spliceosomal complex assembly, Protein localization to endosome and Interferon Gamma Response were enriched in the set of upregulated proteins and these regulated proteins may be classically or non-classically secreted. Furthermore, we found differential enrichment of Creb3L1, ESRRA, YY, ELF2, STAT1 and XBP transcription factors potentially regulating these major pathways.

2022-04-04 | PXD025701 | Pride

Homo sapiens

Project description:Modulation of growth and angiogenesis of OSCC cells with Sal B

| PRJNA141521 | ENA

RNA sequencing of adipose tissue-derived stromal cells (ADSCs) with or without Sal-B addition

Project description:Salvianolic acid B (Sal-B) is the most abundant and bioactive water-soluble compound in Salvia miltiorrhiza. Studies have shown that salvianolic acid B increases the mRNA expression of adipogenic transcription factors, including PPARγ, C/EBPα and PPARα, in 3T3-L1 preadipocytes to increase glucose uptake and mitochondrial respiration, reduce glycerol release and promote adipocyte differentiation. However, the effect of Sal-B on graft fat survival and its specific mechanism have not been investigated. So we dicided using h-ADSCs to see its transcriptomes changing after Sal-B addition.

2021-07-01 | GSE175795 | GEO

Salmonella sp. SAL-007

Project description:salmonella SAL-007 Genome sequencing and assembly

| PRJNA707124 | ENA

Salmonella sp. SAL-020

Project description:Salmonella SAL-020 Genome sequencing and assembly

| PRJNA707128 | ENA

Salmonella sp. SAL-045

Project description:Salmonella SAL-045 Genome sequencing and assembly

| PRJNA707129 | ENA

Sal-DG vs MK-DG

Project description:Sal: Saline. Young male C57BL/6J mice received an injection of saline (5 microL per g body weight). RNA from control mice were extracted 1hr, 2hr, 4hr, and 6hr after MK experimental mice received their last shock treatment. MK: MK-801. Young male C57BL/6J mice received an injection of MK-801 (300 micro-g per g body weight). RNA from control mice were extracted 1hr, 2hr, 4hr, and 6hr after MK experimental mice received their last shock treatment. Keywords: time-course

2003-02-27 | GSE316 | GEO

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