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Changes in H3K27me3 in Tatton-Brown-Rahman Syndrome Neuronal Progenitor Cells

ABSTRACT: Human pluripotent stem cell (hPSC) models of Tatton-Brown-Rahman Syndrome (TBRS) were generated (R882H and P904L), and compared to isogenically paired controls (C-WT and WT, respectively). These models were used to generate MGE-like ventral telencephalic neuronal progenitors (V-NPCs) and dorsally patterned neuronal progenitors modelling the cortical ventricular zone (D-NPCs). Cut and Tag for the tri-methylation of histone H3 at the lysine 27 residue (H3K27me3) was performed, to assess how loss of DNMT3A function due to TBRS-associated mutations affects deposition of H3K27me3

ORGANISM(S): Homo sapiens

PROVIDER: GSE294186 | GEO | 2026/01/01

REPOSITORIES: GEO

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