Single‑cell RNA sequencing unveils fibroblast heterogeneity in proliferative vitreoretinopathy membranes

ABSTRACT: Proliferative vitreoretinopathy (PVR) is a vision-threatening fibrotic disorder characterized by pathological membrane formation, yet its cellular and molecular mechanisms remain incompletely understood. Here, we employed single-cell RNA sequencing (scRNA-seq) to profile 18,213 cells from 5 human PVR membranes (PVRMs), uncovering cellular heterogeneity and novel pathogenic pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE294329 | GEO | 2025/12/13

REPOSITORIES: GEO