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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE294342 | GEO | 2026/07/01

REPOSITORIES: GEO

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse]

Project description:Endometrial stem cells and their regenerative properties are implicated in the pathogenesis of endometriosis. Using single-cell RNA sequencing of the adult mouse endometrial epithelium, we identified a sub-population of aldehyde dehydrogenase 1a1+ (Aldh1a1+) stem-like cells that co-expresses stemness genes (Lgr5, Axin2) and lack proliferative markers (Top2a, Mki67). Using an Aldh1a1cre/ERT2;ROSA26tdTomato reporter mouse, we found that Aldh1a1+ cells give rise to long-lived endometrial cells and contribute to post-partum endometrial repair. Selective ablation of ALDH1A1+ cells with diphtheria toxin (DT) in Aldh1a1cre/ERT2; ROSA26-DTRflox/flox mice decreased glands and FOXA2 expression in vivo. Mouse and human ALDHHI endometrial cells had higher organoid formation capacity and stem-like gene signatures than ALDHLO cells. Ectopic lesion-derived organoids showed higher ALDH activity than patient-matched eutopic cells and displayed enriched pro-inflammatory, stemness, and ciliated cell transcriptomes. Here we provide evidence that ALDH1A1+ cells display progenitor/stem cell characteristics in the endometrium and contribute to the pathology of endometriosis.

2026-07-01 | GSE294256 | GEO

ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [Human]

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse scRNA-seq]

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis

Project description:ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis

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The influence of menstrual cycle and endometriosis on endometrial methylome

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse]

Project description:ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse]

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [Human]

Project description:ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [Human]

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ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse scRNA-seq]

Project description:ALDH1A1+ cells are endometrial progenitors contributing to regeneration and endometriosis [mouse scRNA-seq]

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The influence of menstrual cycle and endometriosis on endometrial methylome

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-02-15 | GSE73950 | GEO

TGFβ signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

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