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Differential contribution of TFE3 isoforms to cell motility and invasion

ABSTRACT: We and other have previously reported that TFE3 migrates as two distinct bands of approximately 72 and 82 kDa in SDS-PAGE. Interestingly, whereas the smaller form of TFE3 is always present in cell lysates, the higher molecular weight form appears only after specific stress conditions, such as prolonged starvation. A recent report suggested that the 82 kDa form does in fact corresponds to TFE3 full length (TFE3-L). It was proposed that the control of TFE3 stability may constitute the main mechanism of TFE3 regulation. There is, however, a critical question that remains to be addressed regarding the role of the 72 kDa TFE3 short isoform (TFE3-S). TFE3-S is expressed at high levels in most cell types and its expression remains constant both under control and stress conditions. Characterizing the nature and regulation of TFE3-S, as well as its potential transcriptional activity and selectivity, is therefore essential to fully understand TFE3 regulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE294493 | GEO | 2025/12/03

REPOSITORIES: GEO

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